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Connecting biomedical education with the medical humanities to advance translational medicine

Mike van Spaandonk, Lies Hoogerwerf, Toine Ten Broeke , Sandra Crnko , Thijs Koorman , Niels Bovenschen , Annet van Royen-Kerkhof , Stefan van Geelen

Nat Med. 2025 Jul 24. doi: 10.1038/s41591-025-03839-9.

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Dual targeting of CD155/ TIGIT and PD-L1/ PD-1 immune checkpoints potentiates NK cell-mediated cytotoxicity in medulloblastoma

Matthijs Monnikhof , Michael Y Schakelaar , Chris Meulenbroeks , Matthias Quist , Alicia Perzolli , Aimee Selten , Celeste J M Koster , Daniëlle S C Maassen , Alba Montoro Canelo , Maureen Fredriks , Myrthe J A Koppers , Kim Clevers , Julia Klein , Vela Kaludjerovic , Jan Meeldijk , Emma W Pijnappel , Heggert G Rebel , Sven van Kempen , Sandra Crnko , Thijs Koorman , Aniello Federico , Francesco Valzano , Pieter Wesseling , Friso G J Calkoen , Jasper van der Lugt , Toine Ten Broeke , Marcel Kool , Niels Bovenschen

Neurooncol Adv. 2025 May 18;7(1):vdaf099. doi: 10.1093/noajnl/vdaf099

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Chimeric antigen receptor-macrophages: Emerging next-generation cell therapy for brain cancer

Myrthe J A Koppers , Matthijs Monnikhof , Jan Meeldijk , Thijs Koorman , Niels Bovenschen

Neurooncol Adv. 2025 Mar 19;7(1):vdaf059. doi: 10.1093/noajnl/vdaf059.

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Undergraduate education as catalyst for public-private partnership in biotechnology

Toine Ten Broeke , Thijs Koorman , Sandra Crnko , Erik Voets , Pauline de Goeje , Michael Y Schakelaar , Heggert G Rebel , Emma W Pijnappel , Jorine G F Sanders , Jan Meeldijk , Rian Terveer-Couperus , Esther L Geven , Gönül Dilaver , Erik van Tilborg , Lucas M P Beekman , Lars Guelen , Niels Bovenschen

Nat Biotechnol. 2025 Feb;43(2):282-283. doi: 10.1038/s41587-025-02552-9.

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A challenge-based interdisciplinary undergraduate concept fostering translational medicine.

Floris A Valentijn, Michael Y Schakelaar, Maria A Hegeman, Willemijn D Schot, Wim J A G Dictus, Sandra Crnko, Toine Ten Broeke, Niels Bovenschen

Biochem Mol Biol Educ. 2024 Mar-Apr;52(2):198-209. doi: 10.1002/bmb.21804

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Temporal Dynamics of Serum Perforin and Granzymes in Three Different Clinical Stages of Virus-Induced Severe Fever with Thrombocytopenia Syndrome

Sukhyun Ryu, Jin Kyeong Choi, Chiara Achangwa, Soojung Cho, Joo-Hee Hwang, Jeong-Hwan Hwang, Niels Bovenschen, Chang-Seop Lee

The American journal of tropical medicine and hygiene, 109(3), 554-558. https://doi.org/10.4269/ajtmh.23-0269

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Cellular immunotherapy for medulloblastoma

Michael Y Schakelaar, Matthijs Monnikhof, Sandra Crnko, Emma W Pijnappel, Jan Meeldijk, Toine Ten Broeke, Niels Bovenschen

Neuro-Oncology 2023 Apr 6;25(4):617-627. doi:10.1093/neuonc/noac236

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Serpin B9 controls tumor cell killing by CAR T cells

Thomas Kimman, Anne Slomp, Anne Martens, Sarah Grabherr, Shuang Li, Eline van Diest, Jan Meeldijk, Jurgen Kuball, Monique C Minnema, Eric Eldering, Niels Bovenschen, Zsolt Sebestyén, Victor Peperzak

Journal for ImmunoTherapy of Cancer, 11(3), Article e006364. https://doi.org/10.1136/jitc-2022-006364

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Linked research hubs train students to tackle societal challenges

Michael Y. Schakelaar, Quique Bassat, Catherine M. Comiskey, Katalin Felvinczi, Jan C. M. Haarhuis & Niels Bovenschen

Nature 2022 Nov;611(7936):449. doi: 10.1038/d41586-022-03665-w.

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Strengthening educational leadership through a teaching-focused full professor career track

Vincent Crone , Frans Prins , Christel Lutz , Irma Meijerman ,Veronique Schutjens , Maarten van der Smagt , Leoniek Wijngaards-de Meij ,Niels Bovenschen and Manon Kluijtmans

Abstract from AMEE 2022, Lyon, France.

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Pediatric medulloblastoma express immune checkpoint B7-H3

S Li, G C Poolen, L C van Vliet, J G Schipper, R Broekhuizen, M Monnikhof, W Van Hecke, J F Vermeulen, N Bovenschen

Clinical and Translational Oncology (2022) 24:1204–1208. https://doi.org/10.1007/s12094-021-02762-y

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